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Q & A
Q&A on TCM Support for Fertility and Pregnancy Health
Below are some questions frequently raised by patients, and the answers with an overview of typical TCM support cycles for fertility and recurrent miscarriage, as well as the advantages of TCM in supporting these health challenges.
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A Comprehensive TCM Support Approach for Fertility and Pregnancy Health
Infertility and recurrent miscarriage are significant challenges for many couples, requiring multifaceted treatment approaches. While Western medicine provides advanced technologies and precision diagnostics, Traditional Chinese Medicine (TCM) offers unique advantages that can complement and enhance these treatments.
1. Recommended Duration of TCM Support for Fertility
Q: How long is the typical TCM support period for fertility?
A: The recommended TCM support period for fertility is generally 3-6 months. This timeframe is grounded in reproductive biology: the complete process of spermatogenesis (sperm production) takes approximately 64-72 days, while oogenesis (egg maturation) requires an average of 90 days from primordial follicle activation to full maturation and ovulation [1][2]. Therefore, a minimum three-month period of TCM support is recommended is necessary to influence the quality of gametes that will be available for conception.
Clinical studies support this time frame.. A randomized controlled trial on Chinese herbal medicine for tubal factor infertility found that a 3-month care cycles combined with laparoscopy significantly improved clinical symptoms, reduced serum inflammatory factors (TNF-α and IL-6), and achieved a 58.0% intrauterine pregnancy rate within one year of follow-up after completing 3 months of TCM care, compared to 34.0% in the control group [3]. Another study on polycystic ovary syndrome (PCOS) infertility demonstrated that while both 3-month and 6-month care cycles were effective, outcomes improved with longer support duration: after 6 months of TCM support cycles, patients showed significantly greater improvements in endometrial thickness, dominant follicle count, and traditional Chinese medicine syndrome scores compared to 3-month outcomes [4].
The 3-6 month recommendation also reflects clinical practice patterns. A retrospective study on TCM combined with IVF reported that participants began Chinese herbal medicine therapy roughly three months before starting their first ovulation induction cycle, with the decision guided by evidence that the process of primordial follicles maturing into fully developed oocytes spans approximately 90 days [1]. In this study, 45 patients who had previously failed IVF cycles underwent TCM support combined with a second IVF cycle, achieving a live birth rate of 42.22% [1].
Q: Is it possible to achieve pregnancy success sooner?
A: Yes, some patients may conceive within 1-2 menstrual cycles. Clinical evidence indicates that while optimal results typically require 3-6 months, pregnancy can occur earlier in certain cases. A clinical study on syndrome-differentiation acupuncture for infertility found that although the support protocol lasted 6 months, the acupuncture group achieved a significantly shorter time to pregnancy compared to the herbal medicine control group [5]. Similarly, a study on Tonifying the Kidney and Regulating the Period of Menses (TKRPM) combined with clomiphene reported mean time to pregnancy of 5.17±1.72 months for the combined therapy group, with some patients conceiving earlier than the 3-month benchmark [6].
However, early conception depends on multiple individual factors, including the specific cause of infertility, patient age (particularly whether under 38 years old), ovarian reserve status, and adherence to the treatment plan [1][4]. Patients with mild ovulatory disorders may respond more quickly than those with complex tubal or male-factor infertility. Nonetheless, for comprehensive regulation of the reproductive system and long-term pregnancy maintenance, completing the full 3-6 month period of TCM care remains the standard recommendation based on the physiological turnover time of gametes and the endometrial environment.
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References
[1] Integrating Traditional Chinese medicine into IVF procedures: a retrospective study. In Vivo. 2025;39(3):1625-1637. https://iv.iiarjournals.org/content/invivo/39/3/1625.full.pdf
[2] Cell Divisions in the Formation of Germ Cells. National Institutes of Health (NIH). https://www.ncbi.nlm.nih.gov/books/NBK219110/table/ttt00014/
[3] Liu HL, et al. Efficacy of Chinese Herbs in Multiple Paths for Tubal Factor Infertility Patients and Their Effects on Serum Inflammatory Factors. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Sep. PMID: 30645837
[4] [Chinese herbal cycle therapy for polycystic ovary syndrome infertility: a clinical observation]. Guangming Journal of Chinese Medicine. 2023;(1):70-73.
[5] [Acupuncture based on syndrome differentiation for infertility: a randomized controlled trial]. Shanghai Journal of Traditional Chinese Medicine. 2014;48(12).
[6] Clinical observation on the effects of TKRPM combined with clomiphene for infertility. International Journal of Traditional Chinese Medicine. 2011.
2. TCM Support for Recurrent Miscarriage and IVF Challenges
Q: I have experienced recurrent miscarriages or repeated IVF failures. Can TCM help?
A: Yes, TCM has a long history of supporting women who experience recurrent miscarriages and repeated implantation failure (RIF). Many patients have benefited from TCM support, especially when used before and during pregnancy. TCM methods, including herbal medicine and acupuncture, may help regulate the body's internal systems, improving fertility and increasing the chances of carrying a pregnancy to term [1][2].
A systematic review and network meta-analysis of 47 randomized controlled trials involving 6,678 women with recurrent pregnancy loss (RPL) found that TCM significantly reduced the miscarriage rate by 50% (RR 0.50, 95% CI 0.45–0.55) and increased the live birth rate by 20% (RR 1.20, 95% CI 1.15–1.25) compared to non-TCM treatment [1]. TCM was also associated with lower preterm birth rates (RR 0.81) and fewer adverse events (RR 0.46) [1].
For patients with repeated IVF failures (repeated implantation failure, RIF), clinical studies have demonstrated that acupuncture combined with Chinese herbal medicine can significantly improve pregnancy outcomes. One randomized controlled trial of 62 RIF patients found that those receiving acupuncture plus herbal medicine achieved higher clinical pregnancy rates, embryo implantation rates, and live birth rates compared to control groups [2]. Another study reported that after 3 months of treatment with acupuncture and Bushen Quyu decoction, patients with RIF showed improved endometrial receptivity, increased uterine artery blood flow, and enhanced hormone secretion [3].
The recommended TCM support period for recurrent miscarriage and RIF is typically 3-6 months [1][4]. Case reports have documented successful outcomes with individualized TCM protocols, with patients achieving full-term live births after prior repeated failures [5].
Q: Is it possible to achieve success earlier with TCM?
A: Yes, some patients have achieved pregnancy success in a shorter period, depending on their overall health, the specific cause of infertility, and the treatment plan. While the standard recommendation is 3-6 months of TCM support, clinical evidence shows that certain patients may conceive earlier.
A case report documented a patient with four previous failed embryo transfers (totaling eight embryos) who successfully conceived naturally after approximately 4 months of TCM treatment—specifically, two months of TCM combined with medication to regulate menstruation, followed by two months of TCM combined with ovulation induction [5]. She went on to deliver a healthy full-term baby boy [5].
Another case series reported that among six patients with various infertility diagnoses (including PCOS, diminished ovarian reserve, and blocked fallopian tubes), successful pregnancies were achieved with TCM treatment durations ranging from 3 to 24 months, demonstrating that response times vary individually [4]. The shortest treatment duration to successful live birth in that series was 3 months [4].
A study on RIF patients found that after one menstrual cycle of acupuncture treatment specifically targeted at improving endometrial blood flow, immediate improvements in uterine receptivity were observed, suggesting that some physiological benefits can occur quickly [6].
Factors that may influence earlier success include:
- Mild ovulatory disorders versus complex tubal or male-factor infertility
- Patient age (younger patients may respond more quickly)
- Adherence to the complete treatment plan
- Specific TCM protocols matched to individual syndrome differentiation
However, for comprehensive regulation of the reproductive system and prevention of subsequent miscarriage, completing the full 3-6 month recommended period of TCM care remains the standard approach based on clinical evidence [1][3][4].
References
[1] Long Z, Zhao H, Liu F, et al. Traditional Chinese medicine for recurrent pregnancy loss: A systematic review and network meta-analysis. Science of Traditional Chinese Medicine. 2026;4(1):87-95. doi:10.1097/st9.0000000000000103
[2] You XM, Jiao YF, Ruan F, et al. Clinical efficacy of acupuncture combined with Chinese herbal medication for recurrent implantation failure infertility of kidney deficiency and blood stasis and its effects on serum p38MAPK and JAK/STAT protein expression. Zhongguo Zhen Jiu. 2023 Nov 12;43(11):1251-6. doi:10.13703/j.0255-2930.20230206-0004. PMID: 38092538
[3] Zhou Q, Song LN, Ma JH, et al. Acupuncture and Bushen Quyu decoction improved endometrial receptivity, hormone secretion, and uterine artery blood flow for repeated implantation failure patients undergoing in vitro fertilization and embryo transfer. Drug Discoveries & Therapeutics. 2024;18(6):362-367. doi:10.5582/ddt.2024.01087
[4] Hullender Rubin LE, Opsahl MS, Wiemer KE, Mist SD, Caughey AB. Impact of whole systems traditional Chinese medicine on in-vitro fertilization outcomes. Reproductive BioMedicine Online. 2015;30(6):666-673. doi:10.1016/j.rbmo.2015.02.008
[5] Yu CY (俞楚仪), Wen XH (温小慧), Ma HX (马红霞), et al. A case report of individualized traditional Chinese medicine treatment for repeated embryo transfer failure. Anhui Medical and Pharmaceutical Journal. 2020;24(12):2368-2370. Chinese.
[6] Immediate effect of electro-acupuncture on endometrial blood flow in patients with recurrent implantation failure: a randomized controlled trial. Chinese Journal of Integrative Medicine. 2024;30(4):291-298. doi:10.1007/s11655-023-3638-3
Advantages of TCM in Treating Infertility and Recurrent Preganancy Loss
Q: What are the advantages of TCM compared with Conventional Medicine (Western Medicine)?
A: Traditional Chinese Medicine (TCM), with its rich history spanning thousands of years, offers a unique and insightful approach that complements modern medical science. The World Health Organization (WHO) has long recognized the value of traditional medicine systems, noting that traditional, complementary, and integrative medicine (TCIM) is "present across all six regions of WHO" and "profoundly rooted in traditional knowledge, cultures, histories and territories" [1]. The WHO's holistic perspective explicitly acknowledges that TCIM "emphasizes the internal connections within the human body and its connection to the environment" [1].
The WHO's newly adopted Global Traditional Medicine Strategy (2025–2034) envisions "universal access to safe, effective and people-centred TCIM for the health and well-being of all" and is guiding Member States toward integrating evidence-based traditional medicine into national health systems [2]. WHO has been actively involved in traditional medicine research since the 1970s, including programs investigating "indigenous plants for fertility regulation" [3]. The organization emphasizes that "no healthcare practices or treatments, be they in biomedicine, public health or in TCIM, will be supported or recommended by WHO unless they are evidence-based," demonstrating that TCM's value is recognized within a rigorous scientific framework [1].
TCM's wisdom and practices provide remarkable advantages, many of which remain underappreciated or not yet fully understood by contemporary medical systems. This is especially true in supporting individuals facing challenges like infertility and recurrent pregnancy loss, offering hope and care grounded in centuries of experience.
1. Holistic Approach and Personalized Support
TCM emphasizes treating the body as an interconnected system rather than focusing solely on individual symptoms. This holistic approach allows practitioners to develop personalized support plans based on each patient's constitution, lifestyle, and specific condition. In the case of infertility and recurrent miscarriage, TCM aims to help balance hormonal levels, enhance immune function, and support emotional well-being [4].
Case studies have demonstrated that TCM support—including weekly acupuncture and Chinese herbal therapy—can be associated with successful live births in women with diminished ovarian reserve (DOR) and recurrent pregnancy loss (RPL) after multiple failed conventional cycles [5]. This comprehensive approach aims to improve the overall reproductive environment, which is essential for conception and pregnancy retention.
2. Safety and Minimal Side Effects
Acupuncture and herbal medicine used in Traditional Chinese Medicine (TCM) are often derived from natural sources, such as plant roots, stems, flowers, fungal organisms, and minerals, rather than synthetic chemical compounds [6, 7]. For example, Ilex hainanensis (a plant used to regulate blood pressure and lipid levels) and Poria cocos (a medicinal fungus) are rich in naturally occurring bioactive components like triterpenes, saponins, flavonoids, and polysaccharides [6, 7].
When administered by competent, licensed practitioners who follow proper safety protocols, both acupuncture and herbal medicine are associated with minimal side effects and a low risk of serious adverse events [8–10]. A systematic review of adverse events related to acupuncture in Australia concluded that "acupuncture is generally a safe modality and serious adverse events after treatment are uncommon when supported with well-established guidelines and practiced by licensed, qualified practitioners" [8]. Similarly, a systematic review of acupuncture case reports found that "if clean needle procedures and proper needling techniques are followed, acupuncture appears to be a safe medical procedure with minimal adverse reactions" [9].
Real-world clinical data support these findings: over a nearly five-year period at the Cleveland Clinic's Traditional Chinese Herbal Medicine Program, 2,407 prescriptions totaling 154,449 doses were administered, with only six mild adverse events reported—none of which were serious [10]. At the Hiroshima University Hospital Kampo Clinical Center, which adheres to strict professional standards, 568 acupuncture sessions reported no serious adverse effects, with only minor side effects such as fatigue or localized pain documented in 10 cases [11].
The most common minor side effects of acupuncture are transient and include bruising, dizziness, fatigue, nausea, and mild pain at needle insertion sites [8, 12]. Importantly, serious adverse events are typically preventable through proper training, correct needling techniques, appropriate herbal processing (e.g., prolonged boiling of toxic herbs like Aconite), and accurate diagnosis [9, 12, 13]. The toxicity-effect relationship in TCM herbs is well-recognized in the literature, with the clinical goal being to achieve maximum therapeutic effect while minimizing toxicity through appropriate dosing and administration [14].
Thus, within competent hands and regulated practice environments, TCM approaches derived from natural sources demonstrate a favorable safety profile.
3. Improving Baseline Health and Long-Term Benefits
TCM doesn't only focus on immediate results but also seeks to support the overall health of the patient. By strengthening key organ systems such as the kidneys, spleen, and liver, TCM helps build a strong foundation for fertility and pregnancy success [4].
A case study of a 34-year-old patient with a 5-year history of infertility caused by diminished ovarian reserve demonstrated that after 4 months of TCM support (including acupuncture and herbal therapy), her FSH levels improved from 14.5 mIU/mL to 8.7 mIU/mL, and her antral follicle count increased from 10-12 to 16-18 [15]. This long-term health improvement may help reduce the risk of recurrent miscarriage and support a healthy pregnancy.
4. Complementing Western Medicine
TCM can work synergistically with Western medicine. A systematic review and meta-analysis of 38 randomized controlled trials involving 5,991 participants found that acupuncture performed during controlled ovarian hyperstimulation (COH) significantly increased the clinical pregnancy rate (RR = 1.33, 95% CI: 1.07-1.65, p = 0.01) for women undergoing IVF fresh cycles [16]. For frozen cycles, acupuncture before freeze-thaw embryo transfer significantly enhanced both the clinical pregnancy rate (RR = 1.71, 95% CI: 1.36-2.16, p < 0.00001) and live birth rate (RR = 2.40, 95% CI: 1.20-4.79, p = 0.01) [16].
An updated systematic review with trial sequential analysis of 42 trials involving 7,400 participants confirmed that acupuncture significantly improved biochemical pregnancy rates (RR = 1.28, 95% CI: 1.04-1.57) and clinical pregnancy rates (RR = 1.19, 95% CI: 1.06-1.34) compared to sham acupuncture and blank controls [17].
Additionally, real-world data from an academic medical center showed that among 146 patients receiving 1,896 Whole Systems TCM support sessions during 202 embryo transfers, patients reported clinically significant mean reductions in pain (-1.38), stress (-2.11), and anxiety (-2.22) within a single session [18].
5. Psychological Regulation and Emotional Management
Stress and emotional well-being play a crucial role in reproductive health. TCM recognizes the connection between emotional balance and fertility, focusing on managing stress, anxiety, and depression that may affect hormonal regulation.
A systematic review and meta-analysis of 12 randomized controlled trials involving 1,930 participants demonstrated that acupuncture significantly improved anxiety scores (including State-Trait Anxiety Inventory, Self-rating Anxiety Scale, and Amsterdam Preoperative Anxiety and Information Scale) and depression scores (Self-rating Depression Scale) in women with infertility [19]. Furthermore, the meta-analysis showed that acupuncture had a significant effect on clinical pregnancy rates, and no adverse events were reported in any of the included studies [19].
Through acupuncture, herbal approaches, and dietary adjustments, TCM helps alleviate stress and support emotional health, thereby creating a more favorable environment for conception and pregnancy.
Conclusion
TCM offers several advantages in supporting individuals with infertility and recurrent miscarriage, particularly due to its holistic approach, safety profile, minimal side effects, and focus on long-term health. It provides a comprehensive supportive option for patients who may not have found success with Western methods alone or for those seeking a natural and less invasive approach. When used alongside Western treatments, TCM may help enhance outcomes, offering patients a supportive pathway toward successful conception and a healthy pregnancy.
References
[1] World Health Organization. Draft global traditional medicine strategy (2025–2034). Executive Board, 156th session. Geneva: WHO; 2024. Available at: https://apps.who.int/gb/MSPI/pdf_files/2025/03/Item2_10-03.pdf
[2] World Health Organization. Global traditional medicine strategy 2025-2034. Geneva: WHO; 2025. ISBN: 978-92-4-011317-6. Available at: https://www.who.int/westernpacific/publications/i/item/9789240113176
[3] Akerele O. WHO's traditional medicine programme: progress and perspectives. WHO Chronicle. 1984. PMID: 6475036
[4] Chen X, Li Y. The role of Traditional Chinese Medicine in infertility and recurrent miscarriage. Journal of Integrative Medicine. 2020;18(5):312-320.
[5] Rubin LH, Opsahl MS, Wiemer KE, Mist SD, Caughey AB. Impact of whole systems traditional Chinese medicine on in-vitro fertilization outcomes. Reproductive BioMedicine Online. 2015;30(6):666-673. doi:10.1016/j.rbmo.2015.02.008
[6] Liu X, et al. A comprehensive review of Ilex hainanensis Merr.: Traditional uses, chemical composition, pharmacological properties, toxicity and clinical applications. Fitoterapia. 2025;186:106783. doi:10.1016/j.fitote.2025.106783
[7] Lei J, et al. A multidimensional perspective on Poria cocos, an ancient fungal traditional Chinese medicine. Journal of Ethnopharmacology. 2025. PMID: 40280371
[8] Safety and side effects of acupuncture therapy in Australia: A systematic review. ScienceDirect. 2019. Available at: https://www.sciencedirect.com/science/article/abs/pii/S1876382018309946
[9] Lao L, Hamilton GR, Fu J, Berman BM. Is acupuncture safe: a systematic review of case reports. Alternative Therapies in Health and Medicine. 2003;9(1):72-83. PMID: 12564354
[10] Roofener G. Lessons in herb safety from The Cleveland Clinic Chinese Herbal Medicine Program. American Herbal Products Association. 2018.
[11] Jiang Y, et al. Analysis of adverse events in acupuncture and moxibustion treatments in Japan and the current situation of Hiroshima University Hospital Kampo Clinical Center. Medical Acupuncture. 2025;37(4):312-319. doi:10.1089/acu.2024.0188
[12] Huang CC, Kotha P, Tu CH, et al. Acupuncture: A review of the safety and adverse events and the strategy of potential risk prevention. American Journal of Chinese Medicine. 2024:1-33. doi:10.1142/S0192415X24500617
[13] Chinese Medicine Regulatory Office, Department of Health, Hong Kong. Adverse Reactions of Chinese Medicines. Available at: https://www.cmro.gov.hk/html/eng/useful_information/public_health/pamphlet/Adverse_Reactions_of_CM.html
[14] Deciphering the toxicity-effect relationship and action patterns of traditional Chinese medicines from a smart data perspective: a comprehensive review. Frontiers in Pharmacology. 2023;14:1278014. doi:10.3389/fphar.2023.1278014
[15] Rubin LH, et al. Diminished ovarian reserve, clomid, and traditional Chinese medicine: a case study. Medical Acupuncture. 2012;24(4):244-249. doi:10.1089/acu.2012.0901
[16] Wang X, et al. The timing and dose effect of acupuncture on pregnancy outcomes for infertile women undergoing in vitro fertilization and embryo transfer: a systematic review and meta-analysis. Journal of Integrative and Complementary Medicine. 2024;30(11):1031-1046. doi:10.1089/jicm.2023.0478
[17] Fu QW, et al. Acupuncture for women undergoing in vitro fertilization: An updated systematic review and meta-analysis with trial sequential analysis. International Journal of Nursing Studies. 2025;166:105030. doi:10.1016/j.ijnurstu.2025.105030
[18] Clinical delivery of whole systems traditional Chinese medicine and impacts upon patient reported outcomes during IVF. PubMed. 2025. PMID: 40475372
[19] Acupuncture treatment for emotional problems in women with infertility: a systematic review and meta-analysis. PubMed. 2023. PMID: 37893778
OPTIMIZING FERTILITY: INTEGRATIVE STRATEGIES BASED ON SCIENTIFIC AND TCM EVIDENCE
Q: We are no longer young and have undergone multiple IVF attempts without success. IVF has already cost us a lot, and we don't want to spend too much on other treatments. We would like to try acupuncture just one or two weeks before egg retrieval and embryo transfer, hoping to quickly improve egg quality and implantation success rates. Do you have any professional advice?
A: For patients who have experienced repeated IVF failures and are seeking cost-effective, evidence-informed approaches, we offer the following professional recommendations based on current scientific literature and integrative medicine principles.
1. Lifestyle Adjustments Are Foundational and Cannot Be Overlooked
The quality of oocytes and sperm is highly dependent on overall health status. Relying solely on acupuncture or herbal medicine without addressing irregular sleep, poor nutrition, and chronic stress may significantly reduce the effectiveness of any support plan.
Evidence for lifestyle factors:
A 2025 review published in The Lancet Regional Health – Western Pacific examined the impact of lifestyle and environmental risks on female fertility. The review found that:
- Physical activity, mental wellbeing, and sleep health are all significant modifiable factors affecting female fertility
- Chronic psychological stress is associated with elevated cortisol levels, which can disrupt the hypothalamic-pituitary-gonadal (HPG) axis—the central neuroendocrine system regulating reproductive function
- Environmental pollutants and lifestyle factors interact with genetic predispositions to influence ovarian reserve and egg quality [1]
Clinical implication: Lifestyle interventions (sleep optimization, stress reduction, balanced nutrition) should be implemented as foundational measures alongside any TCM support, not as optional add-ons.
2. Acupuncture Requires Sufficient Duration—Not Just 1–2 Weeks
Your consideration of trying acupuncture only 1–2 weeks before egg retrieval is not supported by current evidence. The maturation of oocytes is a gradual process requiring approximately 75 to 90 days from primordial follicle activation to preovulatory follicle, involving multiple developmental stages [2].
Physiological basis (90-day oogenesis timeline):
Ovarian follicular dynamics research has demonstrated that human ovarian follicles undergo a prolonged developmental process:
- Primordial follicles are activated and enter the growth phase continuously
- The development from primordial follicle to preovulatory follicle spans approximately 85-90 days (three menstrual cycles)
- During this period, the growing follicle and its oocyte are highly sensitive to endocrine, metabolic, emotional, and nutritional factors [2]
Therefore, attempts to enhance oocyte quality with short-term interventions immediately before retrieval or embryo transfer are generally ineffective. Evidence supports initiating support and lifestyle modifications at least three months prior to IVF to positively influence folliculogenesis and subsequent embryo quality [2].
Evidence from clinical trials:
A systematic review and meta-analysis of 38 randomized controlled trials involving 5,991 participants examined the timing and dose effect of acupuncture on pregnancy outcomes for women undergoing IVF [3].
Key findings:
- Acupuncture during controlled ovarian hyperstimulation (COH): Clinical pregnancy rate RR = 1.33 (95% CI: 1.07-1.65) with P = 0.01 (statistically significant)
- Acupuncture only on the day of embryo transfer: No significant improvement in pregnancy rates (not statistically significant)
- Acupuncture at oocyte retrieval or embryo transfer only: Limited or no benefit (not statistically significant)
The meta-analysis concluded that acupuncture administered only on the day of embryo transfer does NOT demonstrate reproductive benefits, whereas acupuncture performed throughout the COH phase significantly improves clinical pregnancy rates [3].
Evidence from network meta-analysis (2025):
A Bayesian network meta-analysis of 96 randomized controlled trials involving 14,736 participants further confirmed these findings [6]. The study compared multiple acupuncture-related therapies and found:
- Warm acupuncture administered for three full menstrual cycles before oocyte retrieval demonstrated the greatest efficacy, with an odds ratio (OR) of 3.56 (95% credible interval: 2.05-6.25) for clinical pregnancy rates
- Acupuncture-related therapies with a limited number of sessions before or after embryo transfer show minimal clinical benefit
- Longer treatment durations (3 months or longer) and higher session numbers (20 sessions or more) yielded significantly superior outcomes compared to shorter protocols [6]
Clinical recommendation: TCM acupuncture support should begin at least 8-12 weeks before planned egg retrieval, with weekly sessions during the preparatory phase.
3. Combined Acupuncture and Herbal Medicine Is More Effective Than Either Modality Alone
For patients with complex infertility and repeated IVF failures (particularly recurrent implantation failure, RIF), single modalities such as herbal medicine or acupuncture alone often fail to achieve optimal results.
Evidence for combined approach:
A randomized controlled trial of 62 patients with recurrent implantation failure (RIF) diagnosed with kidney deficiency and blood stasis pattern (a TCM syndrome differentiation) compared:
- Observation group: Acupuncture + Chinese herbal medication
- Control group: Conventional treatment alone [4]
Results:
- Clinical pregnancy rate: Observation group was significantly higher than control group (P < 0.05)
- Embryo implantation rate: Observation group was significantly higher than control group (P < 0.05)
- Live birth rate: Observation group was significantly higher than control group (P < 0.05)
- Biochemical pregnancy rate: Observation group was significantly lower than control group (P < 0.05)
- TCM syndrome symptom scores: Observation group showed significantly greater improvement than control group (P < 0.05)
Molecular mechanism evidence:
The same study measured serum protein expression levels and found that the combined acupuncture and herbal medicine intervention:
- Reduced plasma D-dimer levels (indicating improved blood flow and reduced hypercoagulability)
- Lowered serum p38MAPK protein expression (a molecular marker associated with inflammation and implantation failure)
- Modulated JAK/STAT protein expression pathways involved in endometrial receptivity [4]
Clinical implication: For patients with RIF and repeated IVF failures, individualized protocols employing both herbal medicine and acupuncture are recommended to optimize reproductive function, rather than relying on a single modality.
4. Oocyte Quality Improvement Requires Adherence to the 90-Day Physiological Timeline
The process of oogenesis—from primordial follicle activation to preovulatory follicle—spans approximately 90 days (three menstrual cycles) [2].
Factors affecting oocyte quality during this 90-day window:
- Oxidative stress: Excess reactive oxygen species can damage mitochondrial DNA and the meiotic spindle, compromising oocyte quality
- Mitochondrial function: Oocytes require high ATP levels for maturation, fertilization, and early embryogenesis; mitochondrial health is critical
- Ovarian blood flow: Adequate perfusion delivers oxygen, nutrients, and hormonal signals to developing follicles
- Hormonal balance: FSH, LH, estradiol, and progesterone must be coordinated for normal folliculogenesis [2]
Clinical implication: The 90-day window represents the critical period during which interventions can influence egg quality. Any support plan should commence at least three months before planned egg retrieval to allow sufficient time for physiological effects to manifest.
5. Avoid "Trial-and-Error" Logic; Prioritize Systematic, Evidence-Based Care
Repeated IVF cycles without comprehensive optimization may carry potential risks that deserve careful consideration. The so-called "trial-and-error" approach—pursuing repeated IVF attempts without systematic evaluation and optimization of the patient's overall physiological state—may overlook the body's need for recovery and lead to diminished returns.
a) Evidence for Diminished Ovarian Reserve with Repeated Cycles
A large retrospective study of 4,245 infertile women examined factors influencing the rate of anti-Müllerian hormone (AMH) decline—a key biomarker of ovarian reserve [7].
Key findings:
- Undergoing more than three ovarian stimulation cycles was significantly associated with an accelerated rate of AMH decline (P = 0.030)
- This finding suggests that repeated ovarian stimulation cycles may contribute to accelerated depletion of ovarian reserve
- The study specifically highlights "the need for caution regarding the potential impairment of ovarian reserve due to repeated cycles of ovarian stimulation" [7]
- Medical intervention targeting these influencing factors may help mitigate the rate of ovarian reserve loss and delay ovarian aging
For patients with diagnosed diminished ovarian reserve (DOR), a retrospective cohort study of cumulative live birth rates after multiple complete IVF/ICSI cycles found [8]:
- For women under 35 years with DOR: Cumulative live birth rate ranged from 41.1% to 81.0% after multiple cycles
- For women aged 35-39 years with DOR: Cumulative live birth rate ranged from 30.0% to 56.5% after multiple cycles
- For women aged 40 years or older with DOR: Conservative estimates of cumulative live birth rate after 6 cycles was only 14.7% to 26.0%
The study concluded that for DOR patients aged 40 years or older, the benefit of pursuing multiple additional cycles diminishes significantly [8].
b) Evidence for Chronic Stress and Psychological Exhaustion
The psychological burden of repeated IVF cycles is substantial and well-documented in the literature.
Prevalence data:
A systematic review and meta-analysis of 40 studies involving 16,042 participants examined the prevalence of psychological problems among individuals and couples during assisted reproductive technology (ART) treatment [9]:
- For women: 48.0% experienced anxiety symptoms (95% CI: 36.6%–59.9%); 35.6% experienced depression symptoms (95% CI: 28.0%–43.3%); 52.2% experienced stress symptoms (95% CI: 13.2%–91.1%)
- For men: 28.4% experienced anxiety symptoms; 18.6% experienced depression symptoms; 47.2% experienced stress symptoms
Impact on pregnancy outcomes:
A meta-analysis of 29 studies involving 5,411 participants demonstrated that psychological factors significantly affect IVF/ICSI outcomes [10]:
- Higher levels of anxiety were significantly associated with lower likelihood of successful pregnancy (SMD: -0.17, 95% CI: -0.27 to -0.06, P = 0.002)
- Higher levels of depression were significantly associated with lower likelihood of successful pregnancy (SMD: -0.17, 95% CI: -0.30 to -0.04, P = 0.008)
These findings indicate that higher levels of anxiety and depression are significantly associated with a lower likelihood of successful pregnancy following IVF/ICSI treatment [10].
Impact on IVF process stages:
A 2024 systematic review specifically examined the effect of stress on each stage of the IVF procedure [11]:
- Chronic stress significantly and negatively affects the egg retrieval stage of the IVF process
- Stress impacts oocyte yield and maturity
- Psychological distress may also affect embryo development and implantation outcomes
- The review concluded that stress management should be integrated into fertility care protocols [11]
c) Evidence for Disruption of the Hypothalamic-Pituitary-Ovarian (HPO) Axis
The HPO axis is central to reproductive function. In stimulated IVF cycles, multifollicular development results in supraphysiological steroid concentrations, which inhibit luteinizing hormone (LH) secretion by the pituitary via negative feedback at the level of the hypothalamic-pituitary axis [12].
Physiological disruption:
- During controlled ovarian hyperstimulation, estrogen and progesterone levels reach concentrations many times higher than in natural cycles
- These supraphysiological steroid levels suppress endogenous LH secretion through negative feedback at both hypothalamic and pituitary levels
- This disruption necessitates luteal phase support in all stimulated cycles, as the endogenous LH surge is insufficient to support the corpus luteum [12]
- The requirement for exogenous hormone support in every stimulated cycle reflects the consistent disruption of the normal HPO axis
Rare but important cases:
While uncommon, individual case reports have documented paradoxical responses to GnRH agonist protocols in patients with underlying pituitary pathology. One reported case described a patient with an undiagnosed pituitary macroadenoma who exhibited:
- Extreme ovarian hyperstimulation with estradiol levels exceeding 27,000 pmol/L
- Multiple large follicles developing during the expected downregulation phase of GnRH agonist therapy
- This paradoxical response—rather than the expected suppression of ovarian activity—highlights that repeated hormonal stimulation cycles may have complex and unpredictable effects on the neuroendocrine axis, particularly in patients with underlying conditions that have not been previously identified [13]
Clinical implication: While rare, such cases illustrate that the neuroendocrine response to repeated stimulation cycles is not always predictable. A systematic, whole-person evaluation before each cycle—including consideration of undiagnosed endocrine conditions—is a prudent approach.
Summary of Professional Recommendations In Literature
Lifestyle modifications:
- Recommendation: Implement sleep, nutrition, and stress management alongside any TCM support
- Evidence level: Moderate
- Key references: [1]
Acupuncture duration:
- Recommendation: At least 8-12 weeks (3 full cycles) before egg retrieval
- Evidence level: Strong
- Key references: [2][3][6]
Acupuncture session frequency:
- Recommendation: Weekly during preparatory phase; 20 sessions or more total
- Evidence level: Strong
- Key references: [6]
Herbal medicine + acupuncture combined:
- Recommendation: Recommended for RIF and repeated IVF failures
- Evidence level: Strong (RCT)
- Key references: [4]
Treatment start time:
- Recommendation: Minimum 90 days before planned egg retrieval
- Evidence level: Strong (physiological basis)
- Key references: [2]
1-2 week "crash" preparation:
- Recommendation: Not recommended—limited to no clinical benefit
- Evidence level: Strong
- Key references: [3][6]
Repeated cycles without optimization:
- Recommendation: Associated with accelerated AMH decline, psychological distress, and HPO axis disruption
- Evidence level: Moderate to Strong
- Key references: [7][8][9][10][11][12]
Conclusion
If you are facing fertility challenges with multiple previous IVF failures, we strongly recommend consulting with an experienced professional who has knowledge in both Traditional Chinese Medicine and Western Medicine to develop a personalized, phased, and evidence-informed support plan.
The 1-2 week "crash" approach to acupuncture is not supported by current evidence. The physiological reality of a 90-day oogenesis timeline, combined with clinical trial data demonstrating that longer treatment durations (3 months or longer) yield significantly better outcomes, indicates that patience and systematic care are essential.
Science, evidence-based practice, and realistic expectations remain the cornerstones of achieving healthy conception.
Reference
[1] The Lancet Regional Health – Western Pacific. Lifestyle, environmental risks, and female fertility. 2025.
[2] Baerwald AR, Adams GP, Pierson RA. Ovarian follicular dynamics in humans: A review. Reproductive Biology and Endocrinology. 2012;10:91.
[3] Wang X, et al. The timing and dose effect of acupuncture on pregnancy outcomes for infertile women undergoing in vitro fertilization and embryo transfer: A systematic review and meta-analysis. Journal of Integrative and Complementary Medicine. 2024;30(11):1031-1046. doi:10.1089/jicm.2023.0478
[4] You XM, Jiao YF, Ruan F, et al. Clinical efficacy of acupuncture combined with Chinese herbal medication for recurrent implantation failure infertility of kidney deficiency and blood stasis and its effects on serum p38MAPK and JAK/STAT protein expression. Zhongguo Zhen Jiu. 2023. PMID: 38092538
[5] Different effectiveness of acupuncture treatment schedule on ART pregnancy outcomes: a systematic review and network meta-analysis. Frontiers in Endocrinology. 2025. PMID: 40979715
[6] Bin C, Zhong H, Zhang S, et al. Effects of acupuncture-related therapies on pregnancy outcomes among women undergoing in vitro fertilization and embryo transfer: A Bayesian network meta-analysis. Journal of Assisted Reproduction and Genetics. 2025. doi:10.1007/s10815-025-03489-3
[7] Factors influencing the rate of anti-Müllerian hormone decline: a retrospective study of 4245 infertile women. ScienceDirect. 2025. https://www.sciencedirect.com/science/article/abs/pii/S1472648325003256
[8] Retrospective cohort study on cumulative live birth rate of in vitro fertilization/intracytoplasmic sperm injection after multiple complete cycles in patients with diminished ovarian reserve. BMC Pregnancy and Childbirth. 2025;25:755. doi:10.1186/s12884-025-07839-y
[9] Prevalence of psychological problems among individuals and couples during assisted reproductive technology (ART) treatment: a systematic review and meta-analysis. Journal of Assisted Reproduction and Genetics. 2025;42:2805-2816.
[10] Effects of emotions on IVF/ICSI outcomes in infertile women: a systematic review and meta-analysis. Journal of Assisted Reproduction and Genetics. 2025;42:1083-1099. PMID: 39870885
[11] Zanettoullis AT, Mastorakos G, Vakas P, Vlahos N, Valsamakis G. Effect of Stress on Each of the Stages of the IVF Procedure: A Systematic Review. International Journal of Molecular Sciences. 2024;25(2):726.
[12] Humaidan P, et al. The luteal phase after GnRH-agonist triggering of ovulation: present and future perspectives. Reproductive Biomedicine Online. 2012;24(2):134-41.
[13] The Double-Edged Nature of the Gonadotropin-Releasing Hormone Agonist (GnRHa) Long Protocol: A Case of Paradoxical Ovarian Hyperstimulation During the Expected Downregulation Phase. Journal of Clinical Medicine. 2025;14(14):4992.
Fertility & IVF Support
fertility & IVF support, Pediatric conditons
We provide acupuncture and Chinese herbal medicine support with the goal of assisting individuals on their fertility journey. Our practitioners have experience supporting both IVF cycles and natural conception.
Special Note on IVF and Repeated IVF Challenges
Assisted reproductive technology (ART) has helped many individuals and couples conceive. For those considering or currently undergoing IVF, we encourage understanding the full picture—including both the benefits and the broader context in which fertility care is delivered.
Psychological Impact of IVF Treatment
Research indicates that women undergoing IVF may experience significant psychological challenges. A systematic review and meta-analysis of 40 studies involving 16,042 participants found that among women undergoing ART treatment, the prevalence of anxiety symptoms was 48.0% (95% CI: 36.6%-59.9%), depression symptoms was 35.6% (95% CI: 28.0%-43.3%), and stress symptoms was 52.2% (95% CI: 13.2%-91.1%) [1]. Among men undergoing ART, the prevalence was 28.4% for anxiety, 18.6% for depression, and 47.2% for stress [1].
Emotional burden has been identified as one of the primary reasons patients discontinue treatment prematurely. A 2-year prospective study of 310 couples found that the most frequently cited reasons for treatment discontinuation were the emotional burden of treatment (43.6%) and cost (43.7%), followed by physical discomfort (31.4%) and loss of hope regarding treatment (33.3%) [2]. Similarly, a nationwide survey of infertility patients reported that psychological burden and treatment fatigue were cited by 58.0% of respondents as a reason for discontinuing treatment without achieving pregnancy [3].
Impact of Stress on IVF Outcomes
Fertility-related stress has been shown to potentially impact treatment outcomes through both physiological and behavioral pathways. A systematic review examining the effect of stress on each stage of the IVF procedure found that chronic and acute stress significantly and negatively affected the egg retrieval stage, which was the time point most affected by stress [4]. The review also identified associations between chronic stress and the fertilization stage, with follicular cortisol levels affecting multiple stages of the IVF process [4].
Physical Recovery Between Cycles
Regarding physical recovery between cycles, clinical guidance suggests that after a failed cycle or miscarriage, allowing time for the body to recover before attempting another transfer may be beneficial. One fertility clinic guideline specifically recommends that "the interval between two consecutive IVF cycles must not be smaller than 3 months to give the ovaries time to recover, and to yourselves time to recuperate psychologically" [5]. Some sources suggest waiting 1-3 menstrual cycles, which allows the body to physically recover and hormones to regulate [6]. Patients are encouraged to discuss optimal timing with their fertility specialist, as individual circumstances vary.
The goal is not simply to achieve a pregnancy, but to nurture a healthy pregnancy and a healthy parent. Every hopeful parent desires a healthy newborn, and taking steps that support both emotional and physical well-being throughout the journey is essential.
We encourage everyone considering IVF to:
Become informed about the procedure—including its history, methods, success rates, and potential risks—through reliable sources such as patient education materials from registered clinics and health authorities, as well as discussions with their fertility specialist.
Understand that a positive pregnancy test is an early step; ongoing prenatal care and monitoring are essential for a healthy pregnancy outcome.
Prioritize their physical and emotional health before, during, and after treatment, and work collaboratively with their healthcare team to develop a plan that aligns with their values and circumstances.
Prior to conception, during the process, and after becoming pregnant, it is beneficial to be prepared and adjusted both physically and mentally to support optimal health. Creating a supportive internal environment is valuable for the nine-month journey of pregnancy.
Reference
[1] Prevalence of psychological problems among individuals and couples during assisted reproductive technology (ART) treatment: a systematic review and meta-analysis. Journal of Assisted Reproduction and Genetics. 2025;42:2805-2816. doi:10.1007/s10815-025-03456-y
Key findings: 40 studies, 16,042 participants; anxiety 48.0% in women, 28.4% in men; depression 35.6% in women, 18.6% in men; stress 52.2% in women, 47.2% in men.
[2] Péloquin K, et al. Navigating the crossroads: unraveling predictors for treatment discontinuation in couples pursuing assisted reproduction: findings from a 2-year prospective study. Human Reproduction. 2024;39(Supplement_1):deae108.087. doi:10.1093/humrep/deae108.087
Key findings: 310 couples followed for 2 years; most cited reasons for discontinuation: emotional burden 43.6%, cost 43.7%, physical discomfort 31.4%, loss of hope 33.3%.
[3] Identifying Factors Associated with Discontinuation of Infertility Treatment Prior to Achieving Pregnancy: Results of a Nationwide Survey. Journal of Patient Experience. 2024;11:23743735241229380. doi:10.1177/23743735241229380
Key findings: Psychological burden/treatment fatigue cited by 58.0% of respondents as reason for discontinuation; financial burden 62.3%.
[4] Zanettoullis AT, Mastorakos G, Vakas P, Vlahos N, Valsamakis G. Effect of Stress on Each of the Stages of the IVF Procedure: A Systematic Review. International Journal of Molecular Sciences. 2024;25(2):726. doi:10.3390/ijms25020726
Key findings: 36 articles included; chronic and acute stress significantly and negatively affect egg retrieval stage; follicular cortisol affects multiple stages.
[5] Negative test. Eugonia Fertility Clinic. Available at: https://www.eugonia.com.gr/en/ivf/procedure-continued/pregnancy-test/negative-test
Quote: "The interval between two consecutive IVF cycles must not be smaller than 3 months to give the ovaries time recover, and to yourselves time to recuperate psychologically."
[6] IVF after miscarriage: Your guide to next steps. Gaia Family. Available at: https://gaiafamily.com/en-us/learn/editorials/ivf-after-miscarriage-guide
Key recommendation: "Most doctors recommend waiting for one to three full menstrual cycles before starting another IVF cycle. This pause allows your body to physically recover and your hormones to regulate."
Infertility support
The Complex of Pregnancy and Live Birth
Pregnancy leading to the birth of new life is a very complicated process, look at this and you will see how complicated the simple process of ovulation can be. Please watch the below video
Video 1: Ovulation procedure
Video 2: Fertility：A Difficult Encounter and Union — The Story of Sperm and Egg
Increase in infertility rate (1/6 couples)
At the same time, the occurrence of infertility is caused by a variety of complex social living habits and other factors.
Many women who wish to have a successful pregnancy may have heard the older generation say that pregnancy and childbirth are not as difficult as it is now. Indeed, with the development of society, the pollution of the environment, the acceleration of the pace of life and the increase in the pressure, especially working females, women have to bear a lot of work pressure in addition to their families, which explains part of the incidence of infertility The reason why it increases with the development of society.
TCM in the role of fertility support
Check on the Australian Family Physician website for a research article
Traditional Chinese medicine: Women’s experiences in the treatment of infertility
Check below updated research papers about Chinese Medicine & Acupuncture for infertility support
2015 Chinese herbal medicine for female infertility: An updated meta-analysis
2021 Female infertility and herbal medicine: An overview of the new findings
Special Interests in Male & Female Health
The TCM practitioner at this clinic has a special interest in fertility support and draws on years of clinical experience to work collaboratively with individuals and couples—alongside medical professionals who respect and are open to Traditional Chinese Medicine—to explore TCM approaches as part of their fertility journey."
With your patience, you have a high success rate - Haste makes waste.
Women diagnosed with infertility are often understandably anxious to achieve success quickly. However, it is important to recognize that conception is a gradual process: eggs take time to mature and develop, followed by ovulation, fertilization, and successful implantation into the endometrium.
Evidence for TCM Support in Fertility
Traditional Chinese Medicine (TCM) and acupuncture may improve success rates for both natural conception and IVF. The evidence includes:
- Acupuncture during IVF: A systematic review and meta-analysis of 38 randomized controlled trials involving 5,991 participants found that acupuncture during controlled ovarian hyperstimulation significantly increased clinical pregnancy rates in fresh IVF cycles (RR = 1.33, 95% CI: 1.07-1.65, p = 0.01). For frozen embryo transfer cycles, acupuncture before transfer significantly enhanced clinical pregnancy rates (RR = 1.71, 95% CI: 1.36-2.16, p < 0.00001) and live birth rates (RR = 2.40, 95% CI: 1.20-4.79, p = 0.01) [1].
- Treatment duration matters: A network meta-analysis confirmed that longer treatment durations (3 months or longer) and higher session numbers (20 acupuncture sessions or more) yielded superior reproductive outcomes. The analysis found that acupuncture significantly improves clinical pregnancy rates (RR 1.26), live birth rates (RR 1.10), fertilization rates (RR 6.64), and high-quality embryo rates (RR 12.67) [2].
- Herbal medicine support: The Jianpi Antai formula has been shown to improve embryo implantation rates (68.7% vs. 55.9%), clinical pregnancy rates (56.7% vs. 44.8%), and live birth rates (50.7% vs. 37.8%) in infertile women undergoing IVF-ET. Subgroup analysis revealed these benefits were also observed in patients of advanced age (35 years or older) and those with diminished ovarian reserve [3].
- Electroacupuncture for oocyte quality: Studies have demonstrated that electroacupuncture increases high-quality oocyte rates (81.3% vs. 57.6%) and high-quality embryo rates (59.8% vs. 37.7%) in infertility patients [4][5]. The mechanism may involve upregulation of stem cell factor (SCF), insulin-like growth factors (IGF-1 and IGF-2) in follicular fluid, and serum β-endorphin (β-EP), which help improve the ovarian microenvironment and oocyte quality [4][5].
- Herbal medicine combined with IVF: A systematic review of 16 randomized controlled trials involving 2,025 women found that combining traditional herbal medicine with IVF improved clinical pregnancy rates (30.36–63.64% in herbal groups vs. 9.38–47.5% in control groups) and rates of high-quality oocytes and embryos [6].
- Real-world clinical data: A retrospective cohort study of 45 women undergoing a second round of IVF combined with TCM support reported a clinical pregnancy rate of 51.11% and a live birth rate of 42.22% [7].
Key Takeaway: Women who wish to conceive but experience infertility issues generally benefit from close attention and support for at least three menstrual cycles. The evidence consistently indicates that longer treatment durations (3 months or longer) and higher session numbers (20 acupuncture sessions or more) yield superior reproductive outcomes [2]. Haste makes waste.
A Couple-Based Approach May Be More Helpful
The eggs come from the female partner, and the male partner provides the sperm. When both sperm and egg are of good quality, the resulting fertilized egg and embryo are more likely to be viable, leading to higher success rates and healthier newborns.
Evidence for Male Partner Support:
- Chinese herbal medicine for male infertility: A randomized controlled trial involving 164 couples with severe male factor infertility demonstrated that male partners receiving Chinese herbal medicine (Bushen Shengjing Decoction) for 2-3 months prior to intracytoplasmic sperm injection (ICSI) significantly improved outcomes compared to ICSI alone. The TCM-supported group showed:
- Fertilization rate: 85.9% (438/510) vs. 77.9% (394/506) in the control group
- Clinical pregnancy rate: 48.7% (38/78) vs. 32.5% (25/77) in the control group (P < 0.05)
- Significant improvements in sperm density, motility, and viability
- Decreased sperm deformity rates and reduced reactive oxygen species (ROS) levels (P < 0.05) [8]
- Electroacupuncture for sperm quality: A randomized clinical trial found that male patients receiving Coenzyme Q10 plus electroacupuncture (EA) showed significant improvements in sperm motility (from 41.40% ± 13.33 to 56.40% ± 11.78, P < 0.001) and total motile sperm count (TMSC) (from 33.59 × 10⁶ ± 27.91 to 78.63 × 10⁶ ± 58.38, P = 0.001), while the Coenzyme Q10-only group showed no significant improvement. The study concluded that combining EA with pharmacological therapy improves sperm parameters more effectively than pharmacological treatment alone [9].
- Transcutaneous electrical acupoint stimulation (TEAS): A meta-analysis of four randomized controlled trials with 321 subjects found that 100 Hz TEAS significantly improved the percentage of grade A sperm in patients with idiopathic oligoasthenospermia (WMD: 6.83, 95% CI: 2.10 to 11.57) [10].
Scientific Mechanism:
The Nrf2 signaling pathway is central to the pathogenesis of oligoasthenozoospermia (OAS) through the regulation of oxidative stress, ferroptosis, autophagy, apoptosis, and endocrine homeostasis [11]. TCM interventions, characterized by multi-component and multi-target actions, activate Nrf2, which is associated with:
- Scavenging reactive oxygen species
- Suppressing lipid peroxidation and ferroptosis
- Stabilizing mitochondrial function
- Mitigating apoptosis
- Repairing the blood-testis barrier
- Preserving testicular microenvironmental homeostasis [11]
Key Takeaway: While addressing female factors alone can be beneficial, simultaneous support for both partners—improving egg quality through ovarian support and hormonal regulation while enhancing sperm parameters including count, motility, morphology, and DNA integrity via antioxidant and anti-inflammatory mechanisms—creates optimal conditions for conception and healthy embryo development. This integrated, couple-based approach aligns with the evidence that both parental contributions are essential for successful pregnancy outcomes.
References
[1] Wang X, et al. The timing and dose effect of acupuncture on pregnancy outcomes for infertile women undergoing in vitro fertilization and embryo transfer: A systematic review and meta-analysis. Journal of Integrative and Complementary Medicine. 2024;30(11):1031-1046. doi:10.1089/jicm.2023.0478
[2] Different effectiveness of acupuncture treatment schedule on ART pregnancy outcomes: a systematic review and network meta-analysis. PubMed. 2025. PMID: 40979715
[3] Liu Q, et al. Chinese medicine Jianpi Antai formula improves pregnancy outcomes of in vitro fertilization-embryo transfer in infertile women. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024;53(3):306-312. PMID: 38749927
[4] Cui W, et al. [Effect of electroacupuncture on oocyte quality and pregnancy for patients with PCOS undergoing IVF-ET]. Zhongguo Zhen Jiu. 2011;31(8):687-91. PMID: 21894688
[5] Lian F, et al. [Improvement of the oocyte quality with electroacupuncture in infertility patients of kidney deficiency pattern]. Zhongguo Zhen Jiu. 2015;35(2). PMID: 25854012
[6] Clinical Research of the Effect of Traditional Herbal Medicine with In Vitro Fertilization and Embryo Transfer. PubMed. KCI. 2025.
[7] Wang SC, et al. The Effectiveness of Live Birth Rate of Traditional Chinese Medicine Intervention for Infertile Women Undergoing a Second Round of IVF Is Influenced by Age. In Vivo. 2025;39(3). PMID: 40294989
[8] Zhang HQ, Zhao HX, Zhang AJ, et al. [Male infertility with severe oligospermatism and azoospermia treated by Bushen Shengjing Decoction combined with intracytoplasmic sperm injection]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27(11):972-975. PMID: 18173138
[9] Budihastuti UR, Murti B, Prakosa T, et al. Effect of electroacupuncture on total motile sperm count and sperm motility. Journal of Public Health Research. 2024;13(3):22799036241272394. doi:10.1177/22799036241272394
[10] Gong Y, Li J, Wu XK. [Transcutaneous electrical acupoint stimulation for the treatment of idiopathic oligoasthenospermia: A meta-analysis]. Zhonghua Nan Ke Xue. 2021;27(10):917-926. PMID: 34914271
[11] Li S, et al. Mechanisms of Traditional Chinese Medicine in regulating Nrf2-related signaling pathways for the treatment of Oligoasthenozoospermia: A review. Journal of Ethnopharmacology. 2026. PMID: 41485624
Miracle in fertilization to embryonic develpment
Check for the below website for the miracle procedure of pregnancy!
There are a lot for scientists to know what is going on in the magic procedure -- That is one of reasons why we need Chinese Medicine approaches to assist to success rate. Please watch the below video
Video 3: Pregnancy Procedure - YouTube
Australian Compliance Disclaimer
Important Notice for Australian Readers:This information is provided for educational purposes only and does not constitute medical advice. The term "TCM support" or "TCM care" is used throughout this document to describe complementary approaches that may assist individuals undergoing fertility treatment. These approaches are not claimed to cure, treat, or replace conventional medical care.
- Individual results vary significantly and cannot be guaranteed
- All medical decisions, including fertility treatment, should be made in consultation with qualified healthcare professionals
- The evidence cited herein is derived from peer-reviewed research but does not constitute a guarantee of outcomes
- TCM practitioners in Australia are regulated by the Chinese Medicine Board of Australia (CMBA) under AHPRA
- Patients should always disclose all TCM supplements and therapies to their primary IVF specialist to ensure coordinated, safe care. At the same time, patients are encouraged to seek practitioners who respect an integrative, evidence-informed approach to fertility.
Please consult with your IVF specialist and a registered TCM practitioner before making any changes to your fertility care plan.
We encourage open communication and collaboration between all healthcare providers involved in your care. Our practitioners are happy to work alongside your fertility specialist with your consent.